CANAGLIFLOZIN AND RISK OF AMPUTATION IN PATIENTS WITH TYPE 2 DIABETES


Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure

Summary: Spliceosome machinery mutations are common early mutations in myeloid malignancies; however, Relaxation effective targeted therapies against them are still lacking.In the current study, we used an in vitro high-throughput drug screen among four different isogenic cell lines and identified RKI-1447, a Rho-associated protein kinase inhibitor

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Lung mitochondrial DNA copy number, inflammatory biomarkers, gene transcription and gene methylation in vapers and smokers

Summary: Background: Mitochondrial DNA copy number (mtCN) maintains cellular function and homeostasis, and is linked to nuclear DNA methylation and gene expression.Increased mtCN in the blood is ROSE PETAL associated with smoking and respiratory disease, but has received little attention for target organ effects for smoking or electronic cigarette

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